Table 2.
Warfarin pharmacodynamics during treatment with herbal medicines (n= 11)
| Mean (95 % CI) | Geometric mean ratio (90% CI) | ||||
|---|---|---|---|---|---|
| Parameter | Warfarin | Warfarin and policosanol | Warfarin and echinacea | Warfarin and policosanol to warfarin only | Warfarin and echinacea to warfarin only |
| INR0 | 1.0 (1.0, 1.0) | 1.0 (1.0, 1.1) | 1.0 (1.0, 1.1) | 1.04 (1.01, 1.07) | 1.01 (0.98, 1.04) |
| INRmax | 1.7 (1.5, 1.9) | 1.9 (1.7, 2.1) | 1.8 (1.6, 2.0) | 1.08 (0.99, 1.18) | 1.04 (0.95, 1.13) |
| AUCINR | 52.7 (38.3, 67.2) | 55.2 (41.2, 69.2) | 55.2 (42.8, 67.6) | 1.11 (0.92, 1.33) | 1.09 (0.91, 1.31) |