Table I.
Levels of serum Ig isotypic Abs in NOD.B10-H2b.C-Stat6+/+ vs NOD.B10-H2b.C-Stat6−/− mice
C57BL/6J |
NOD. B10-H2b C-Stat6+/+ |
NOD. B10-H2b C-Stat6−/− |
|
---|---|---|---|
Ig Isotypes | (n = 3) | (n = 5) | (n = 5) |
IgM | 91.6 ± 4.4a | 112.7 ± 1.8 | 49.5 ± 1.9b |
IgG1 | 345.7 ± 5.4 | 561.7 ± 4.6 | 60.5 ± 4.6b |
IgG2a | 150.6 ± 2.8 | 244.8 ± 6.7 | 149.4 ± 4.9c |
IgG2b | 38.5 ± 2.6 | 125.2 ± 1.3 | 100.2 ± 1.5c |
IgG3 | 58.1 ± 3.0 | 58.0 ± 1.1 | 50.8 ± 1.1b |
IgA | 115.8 ± 1.1 | 115.8 ± 1.1 | 67.6 ± 1.3b |
IgE | 20.9 ± 1.4 | 60.8 ± 1.3 | 6.1 ± 0.9b |
Values are given as micrograms per milliliter ± SE.
Value of p < 0.001 for comparisons between NOD.B10-H2b.C-Stat6+/+ and NOD.B10-H2b.C-Stat6−/− mice.
NS for comparisons between NOD. B10-H2b.C-Stat6+/+ and NOD.B10-H2b.C-Stat6−/− mice.