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. Author manuscript; available in PMC: 2011 Apr 15.
Published in final edited form as: Cancer Res. 2010 Apr 13;70(8):3042–3051. doi: 10.1158/0008-5472.CAN-09-3761

Figure 6. Host contributions of α4β1 integrin to tumor lymphangiogenesis and metastasis.

Figure 6

(A-C) LLC tumors were implanted in integrin α4Y991A mice transplanted with WT or α4Y991A bone marrow and in WT mice transplanted with α4Y991A or WT bone marrow. (A) Mean Lyve-1+ vessels/ field+/- SEM (n=10, *p<0.05). (B) Average percent mice with lymph node metastases +/- SEM (n=10, *p<0.05). (C) Lyve-1 immunostaining of 20μm tumor cryosections; Lyve-1/DAPI immunostaining of 5μm tumor sections; and cytokeratin (green)/DAPI (blue) immunostaining of 5μm lymph node cryosections from A-B. Scale bars indicate 50μm.