Table 4.

Pair-wise comparisons of methylation scores with between sporadic MSI and MSH2-deficient Lynch syndrome CRCs and MSH2 methylation status

	No.	Mean Methylation Score (95%CI)
Sporadic MSI	15	3.00 (1.89–4.11)
Lynch Syndrome with MSH2 methylation	10	2.40 (1.50–3.30)
Lynch Syndrome with MSH2 unmethylation	34	1.12 (0.86–1.37)
MSS	207	0.72 (0.58–0.86)

Pairwise Comparison	P value*
Sporadic MSI vs. Lynch Syndrome with MSH2 Methylation	0.8684
Sporadic MSI vs. Lynch Syndrome with MSH2 Unmethylation	0.0044
Sporadic MSI vs. MSS	<0.0001
Lynch Syndrome with MSH2 Methylation vs. Lynch Syndrome with MSH2 Unmethylation	0.0033
Lynch Syndrome with MSH2 Methylation vs. MSS	0.0001
Lynch Syndrome with MSH2 Unmethylation vs. MSS	0.0024

P values were based on Steel-Dwass test.