Table 1.
Relative ratioa of EBV-EA activation with respect to positive control in presence of dehydrozingerone analogs.
| Compound | Percentage EBV-EA positive cells |
IC50 | |||
|---|---|---|---|---|---|
| Compound concentration (mol ratio/TPAb) | |||||
| 1000 | 500 | 100 | 10 | ||
| Dehydrozingerone (1)c | 0 (70) c | 44.2 | 75.5 | 95.4 | 372 |
| 4 | 0 (70) | 46.7 | 77.7 | 97.6 | 380 |
| 5 | 0 (70) | 44.1 | 74.6 | 94.3 | 369 |
| 6 | 0 (70) | 45.8 | 76.9 | 96.3 | 378 |
| 7 | 0 (70) | 48.6 | 78.1 | 98.9 | 378 |
| 8 | 0 (70) | 42.2 | 73.7 | 93.1 | 368 |
| 9 | 0 (70) | 43.9 | 74.8 | 95.3 | 370 |
| 10 | 0 (60) | 51.3 | 79.4 | 98.0 | 385 |
| 11 | 0 (60) | 53.4 | 81.0 | 99.0 | 389 |
| 12 | 0 (60) | 37.2 | 79.4 | 100 | 379 |
| 13 | 0 (60) | 38.6 | 81.5 | 100 | 381 |
| 14 | 0 (60) | 37.9 | 80.7 | 100 | 380 |
| 15 | 0 (60) | 37.2 | 80.3 | 100 | 380 |
a
Values represent percentages relative to the positive control value (100%).
b
TPA concentration is 20 ng/mL (32 pmol/mL).
c
Values in parentheses are viability percentages of Raji cells.