Table 1.
Spearman rank order r and p-values for relationships between the magnitude of sensitization (Day 7/Day 1), GluR1 S/l ratio, pERK2/ERK2, pCaMKII/CaMKII, pCaMKII/total protein, CaMKII/total protein and overall PKA substrate phosphorylation in saline (SAL), all cocaine-exposed (ALL), sensitized (SENS) and non-sensitized (NON) rats on WD1, WD7, and WD21
| Day 7/Day 1 |
GluR1 S/1 |
pERK2/ERK2 |
pCAMKII/CaMKII |
pCAMKII/total protein |
Total CAMKII/ Total Protein |
|||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Measure | SAL | ALL | SENS | NON | SAL | ALL | SENS | NON | SAL | ALL | SENS | NON | SAL | ALL | SENS | NON | SAL | ALL | SENS | NON | SAL | ALL | SENS | NON | ||
| WD 1 | GluFM S/l | r | –0.33 | 0.02 | –0.26 | – 0.89 | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| p | 0.33 | 0.94 | 0.66 | 0.00 | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | ||
| pERK2/ERK2 | r | 0.26 | 0.06 | 0.14 | 0.60 | –0.01 | –0.63 | –0.43 | –0.68 | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | |
| p | 0.42 | 0.81 | 0.80 | 0.08 | 0.97 | 0.02 | 0.42 | 0.07 | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | ||
| pCAMKII/CaMKII | r | 0.13 | – 0.59 | –0.32 | –0.38 | –0.35 | 0.13 | 0.31 | 0.11 | 0.43 | 0.03 | 0.60 | –0.43 | – | – | – | – | – | – | – | – | – | – | – | – | |
| p | 0.67 | 0.02 | 0.44 | 0.32 | 0.31 | 0.67 | 0.56 | 0.78 | 0.18 | 0.90 | 0.24 | 0.26 | – | – | – | – | – | – | – | – | – | – | – | – | ||
| Overall PKA | r | 0.36 | –0.09 | –0.32 | –0.30 | –0.42 | 0.23 | –0.77 | 0.75 | 0.30 | –0.21 | 0.09 | –0.37 | 0.80 | 0.01 | 0.07 | –0.10 | – | – | – | – | – | – | – | – | |
| p | 0.27 | 0.74 | 0.44 | 0.41 | 0.21 | 0.44 | 0.10 | 0.04 | 0.35 | 0.45 | 0.92 | 0.31 | 0.00 | 0.95 | 0.84 | 0.79 | – | – | – | – | – | – | – | – | ||
| WD 7 | GluFM S/l | r | 0.47 | 0.58 | 0.60 | –0.11 | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| p | 0.14 | 0.00 | 0.02 | 0.78 | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | ||
| pERK2/ERK2 | r | 0.41 | 0.16 | 0.32 | 0.04 | 0.53 | 0.44 | 0.43 | 0.43 | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | |
| p | 0.10 | 0.46 | 0.27 | 0.89 | 0.03 | 0.04 | 0.14 | 0.30 | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | ||
| pCAMKII/CaMKII | r | 0.08 | 0.06 | 0.26 | 0.25 | 0.15 | –0.11 | –0.04 | –0.14 | –0.43 | 0.30 | 0.42 | 0.04 | – | – | – | – | – | – | – | – | – | – | – | – | |
| p | 0.77 | 0.77 | 0.36 | 0.47 | 0.57 | 0.65 | 0.89 | 0.72 | 0.09 | 0.18 | 0.19 | 0.89 | – | – | – | – | – | – | – | – | – | – | – | – | ||
| pCAMKII/total protein | r | –0.05 | –0.01 | –0.03 | 0.18 | –0.24 | –0.20 | –0.21 | –0.26 | –0.04 | –0.12 | –0.05 | –0.17 | – | – | – | – | – | – | – | – | – | – | – | – | |
| p | 0.82 | 0.98 | 0.91 | 0.61 | 0.34 | 0.37 | 0.45 | 0.66 | 0.88 | 0.58 | 0.86 | 0.64 | – | – | – | – | – | – | – | – | – | – | – | – | ||
| CaMKII/total protein | r | 0.02 | –0.05 | –0.18 | 0.03 | –0.10 | –0.13 | –0.18 | –0.26 | 0.47 | –0.31 | –0.35 | –0.25 | – | – | – | – | – | – | – | – | – | – | – | – | |
| p | 0.94 | 0.82 | 0.53 | 0.91 | 0.70 | 0.59 | 0.55 | 0.66 | 0.07 | 0.18 | 0.28 | 0.49 | – | – | – | – | – | – | – | – | – | – | – | – | ||
| Overall PKA | r | –0.12 | –0.25 | –0.53 | 0.19 | 0.17 | –0.41 | –0.49 | –0.11 | 0.14 | – 0.43 | –0.34 | –0.50 | 0.39 | 0.13 | 0.05 | 0.20 | 0.14 | 0.55 | 0.58 | 0.45 | 0.15 | 0.43 | 0.50 | 0.42 | |
| p | 0.62 | 0.25 | 0.06 | 0.58 | 0.48 | 0.08 | 0.10 | 0.78 | 0.58 | 0.05 | 0.30 | 0.13 | 0.12 | 0.55 | 0.87 | 0.56 | 0.58 | 0.01 | 0.04 | 0.20 | 0.57 | 0.05 | 0.09 | 0.24 | ||
| WD 21 | GluR1 S/l | r | –0.18 | 0.51 | 0.58 | –0.01 | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| p | 0.46 | 0.00 | 0.01 | 0.97 | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | ||
| pERK2/ERK2 | r | –0.23 | 0.36 | 0.36 | 0.36 | 0.62 | –0.06 | –0.39 | –0.20 | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | |
| p | 0.36 | 0.12 | 0.39 | 0.24 | 0.01 | 0.81 | 0.34 | 0.53 | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | |||
| pCAMKII/CaMKII | r | –0.11 | –0.06 | 0.15 | –0.07 | –0.06 | – 0.47 | – 0.67 | –0.34 | 0.30 | 0.09 | 0.17 | 0.01 | – | – | – | – | – | – | – | – | – | – | – | – | |
| p | 0.66 | 0.79 | 0.68 | 0.82 | 0.79 | 0.03 | 0.04 | 0.26 | 0.22 | 0.71 | 0.66 | 0.96 | – | – | – | – | – | – | – | – | – | – | – | – | ||
| Overall PKA | r | –0.12 | 0.38 | –0.32 | 0.22 | –0.06 | 0.48 | 0.57 | 0.15 | –0.28 | 0.28 | –0.10 | 0.34 | –0.10 | – 0.64 | – 0.75 | – 0.57 | – | – | – | – | – | – | – | – | |
| p | 0.62 | 0.08 | 0.35 | 0.48 | 0.80 | 0.03 | 0.10 | 0.62 | 0.26 | 0.23 | 0.79 | 0.27 | 0.69 | 0.00 | 0.01 | 0.04 | – | – | – | – | – | – | – | – | ||
Shaded boxes indicate statistically significant corrections.