Figure 5.

IMAC-mediated Ψ_M oscillations triggering an MPTP-mediated final depolarization wave. (A) Space-time plot of Ψ_M recorded along the yellow line indicated at the left. O⁻₂ production rate increased progressively over time, most rapidly in the lower four rows of mitochondria (where k_shunt = 0.35[0.3 + 0.7 min (1,e^0.02t/150)]), and more slowly elsewhere (k_shunt = 0.2[0.3 + 0.7 min (1,e^0.02t/150)]). (B) Average Ψ_M versus time. (C) Mitochondrial O⁻₂ (blue) and H₂O₂ (red) concentrations versus time. k_shunt was initially zero and started to increase at the upward arrows. Black bar below the snapshot indicates the final MPTP-mediated slow wave.