Figure 3.

Immunohistochemical analysis of the spindle proteins AURKA, AURKB, MAD2 and BUB1B in normal human testes (upper row), seminomas (middle row) and embryonal carcinomas (lower row). A few spermatocytes weakly positive for AURKA can be seen in normal testis. In the cancerous tissues AURKA was expressed more abundantly. AURKB was not expressed in normal testis, and the extent of AURKB expression in cancerous tissues was very limited. The spindle checkpoint proteins MAD2 and BUB1B were highly expressed in both normal and cancerous tissues