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. 2010 Apr 21;98(8):1649–1657. doi: 10.1016/j.bpj.2009.12.4318

Figure 2.

Figure 2

(a) External forces acting on protein groups due to interaction with CO passing through channels. Arrows in yellow, orange, and green represent the external forces upon the migrations between DP and Xe4, Xe4 and Xe2, and Xe2 and Xe1, respectively. DP, Xe4, Xe2, and Xe1 are denoted by arrows in magenta. Three-dimensional free energy map of the CO migration pathway with grid spacing of 0.2 Å reported in Nishihara et al. (17) is also shown. Dots indicate the free energy. (b) Large components of protein conformational changes in response to the external forces shown in panel a. Color scheme for arrows is the same as that used in panel a.