Table 1.

Modeling parameters

Parameters	Symbol	Values
Cytoplasmic volume	Vc	230 μm3
Network polymerization
Base network density	θ0	10−3
Base network turnover time	τn	20 s
Messenger concentration	m	0–13
Equilibrium network	θeq = θ0(1 + m)	10−3 – 1.3 × 10−2
Messenger diffusion coefficient	Dm	1 μm2 s−1
Messenger decay time	τm	1 s
Messenger penetration depth	$d_{\mathrm{m}}=\sqrt{D_{\mathrm{m}}{\tau }_{\mathrm{m}}}$	1 μm
Messenger emissivity	εm	0 – 2 × 10−3
Momentum equation
Specific network viscosity	ν0	5 × 10−4 Pa s
Disjoining force strength	ψ0nMdMmθn	mθn × 10 mN m−1
Attractive force strength	ψ0nSdSεm	εm × (− 400 mN m−1)
Network-solvent drag	H	160 pN s μm−4

Cytoplasmic volume computed from observed volume of spherical keratocytes in suspension (J. Lee, University of Connecticut, private communication, 2008). Parameters related to network concentration, viscosity, and network-solvent drag derived from neutrophil data and modeling (see (12,13), and references therein). Attractive and disjoining force strengths are the minimum values required to drive the correct flattening ratio and the correct velocities.