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IGF-1 induces phosphorylation of TACE in a PKC-dependent manner. A, relative abundance of phosphorylated TACE in cell lysate from SH-SY5Y cells treated with 10 nm IGF-1 for 18 h in the absence or presence of 5 μm bisindolylmaleimide XI (BIM11) or in the absence of IGF-1 (C). Data represent mean ± S.E., n = 3. **, p < 0.01 and **, p < 0.01 significantly different from cells treated with IGF-1. B, representative SDS-PAGE gel analyzed by autoradiography. IP, immunoprecipitation.
