FIGURE 3.

Age-dependent accumulation of mutant htt in glial cells of htt-98Q transgenic mice. A, immunohistochemical staining with 1C2 shows the presence of mutant htt in the white matter (WM) of the corpus callosum in htt-98Q, but not in WT mice at the age of 9 months. B, wild-type and htt-98Q mice at 19 months of age were examined using 1C2 immunocytochemical staining. Note that mutant htt is expressed in glial cells in the WM of the corpus callosum and brain stem (B.S.) in htt-98Q mice. Scale bars: 10 μm.