FIGURE 7.

Neurological phenotypes of double transgenic mice expressing mutant htt in neuronal and glial cells. A, comparison of latency to fall of mice of different genotypes, including double transgenic mice expressing htt-98Q or htt-160Q. Mice at the age of 11–12 or 18–19 weeks (n = 8–12 each group) were compared. *, p < 0.05; **, p < 0.01. B and C, body weight (B, n = 8–10) and survival plot (C, n = 7–11) of mice of different genotypes showing that double transgenic mice lose more body weight (p < 0.05 after 14 weeks) and die earlier than N171–82Q mice.