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. 2010 Feb 4;285(14):10832–10840. doi: 10.1074/jbc.M109.091629

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© 2010 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 4. — PMK-1 MAPK is necessary for host defense against Y. pestis in the nematode C. elegans. Kaplan-Meier survival analysis of C. elegans strains challenged with Y. pestis KIM5. N2 wild-type animals were treated with either a control vector or pmk-1 RNAi. Strain KU25 contains the pmk-1(km25) deletion allele. Survival assays were performed as described under “Materials and Methods,” and animal survival was monitored every 12–24 h. Log rank analysis confirmed a significant decrease in survival following RNAi knockdown of pmk-1 (p < 0.0001) and a significant decrease in survival in strain KU25 (p < 0.0001) when compared with N2 animals.