TABLE 2.
Y. pestis induces expression of transcripts similar to those regulated by PMK-1
Genes showing a significant change in expression during Y. pestis infection (p < 0.05; see supplemental Table 1) were compared with genes regulated by the PMK-1 pathway (20). Those genes whose expression significantly changed in response to Y. pestis and that are dependent upon pmk-1 are shown.
| Description | Sequence ID | Y. pestis regulationa | pmk-1 regulationb |
|---|---|---|---|
| CUB-like | F35E12.5 | 62.54 | 3.6 |
| C32H11.12 | 9.97 | 5.0 | |
| F08G5.6 | 6.21 | 28.9 | |
| C17H12.8 | 5.28 | 8.3 | |
| F55G11.8 | 4.68 | 6.8 | |
| K08D8.5 | 4.07 | 3.5 | |
| C-type lectin | F56D6.2 | 9.24 | 5.0 |
| ZK666.6 | 6.88 | −3.3 | |
| DUF274 | Y41D4B.16 | 7.96 | 3.3 |
| Peptidase | K10C2.3 | 5.12 | 2.5 |
| Metridin-like Shk toxin | F01D5.3 | 2.48 | 3.3 |
| Lysozyme | F58B3.2 | −2.33 | −2.9 |
a Fold-change of transcript expression was following 24 h of Y. pestis infection in wild-type N2 animals.
b Fold-change of transcript expression in daf-2(e1368) animals was compared with daf-2(e1368); pmk-1(km25) animals, as described previously (20).