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. 2010 Feb 5;285(14):10870–10879. doi: 10.1074/jbc.M109.004200

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© 2010 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 4. — Overexpression of CUL7 in JEG-3 cells enhanced cell invasion and migration (A and B). Representative images of filters containing invaded cells in the Matrigel invasion assay (A) or Transwell cell migration assay (B) are shown. White arrows indicate pores on the filter of the Transwell. Bar graphs show the statistical analysis of three independent experiments (t test; **, p < 0.01). C, silencing CUL7 by siRNA in JEG-3 cells stably transfected with CUL7 decreased the migration capacity of JEG-3 cells based on Transwell cell migration assay (t test; **, p < 0.01). D, silencing of E-cadherin by siRNA resulted in increased migration capacity of JEG-3 cells, based on Transwell cell migration assay (t test; *, p < 0.05). Below the graphs are representative immunoblots showing the efficiency of overexpression or RNAi.