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Sphingolipid levels are elevated in serum of Sgpl1−/− mice. Sphingolipid levels were determined in serum of Sgpl1−/− (gray bars) and Sgpl1+/+ (open bars) mice by LC-MS. A, total ceramide (Cer), sphingosine (Sph). B, total sphingomyelin (SM). C, individual ceramide fatty acid chain species. D, individual sphingomyelin fatty acid chain species. Data represent mean values ± S.E. n = 3. *, p < 0.05; **, p < 0.01; ***, p < 0.005, paired Student's t test.
