FIGURE 8.

Lack of renal pathology in the CerS2 null mouse. A, transverse section of the kidney of an 11-month-old CerS2 null mouse. The tips of the interlobar veins, located near the corticomedullary junction, are uniformly small (arrows). These structures were suggested to be tissue clefts (6), but our data suggest that they are normal renal veins (see further discussion in supplemental Fig. 1). B, SL levels were measured by electrospray ionization-tandem mass spectrometry in 4-month-old kidney from WT and CerS null mice. n = 2. *, p < 0.05; **, p < 0.01.