TABLE 1.
KEGG pathway enrichment analysis of differentially expressed genes in 30-day-old CerS2 mouse liver versus WT
KEGG pathway analysis was performed with WebGestalt using the hypergeometric test. The top 20 pathways enriched in both down-regulated and up-regulated genes are shown. The top pathway of both up- and down-regulated genes is shown graphically in supplemental Fig. 2. PPAR is peroxisome proliferator-activated receptor; MAPK, mitogen-activated protein kinase.
| p value | |
|---|---|
| Down-regulated genes | |
| PPAR signaling pathway | 1.01E-10 |
| Metabolism of xenobiotics by cytochrome P450 | 7.55E-08 |
| Insulin signaling pathway | 1.60E-07 |
| Arachidonic acid metabolism | 9.85E-07 |
| Linoleic acid metabolism | 1.14E-06 |
| C21-steroid hormone metabolism | 3.95E-06 |
| Pyruvate metabolism | 1.15E-05 |
| Benzoate degradation via CoA ligation | 1.20E-05 |
| Nitrogen metabolism | 2.21E-05 |
| Glycolysis/gluconeogenesis | 2.34E-05 |
| Glycine, serine, and threonine metabolism | 4.28E-05 |
| Fatty acid metabolism | 5.03E-05 |
| Starch and sucrose metabolism | 1.09E-04 |
| Androgen and estrogen metabolism | 1.11E-04 |
| Tyrosine metabolism | 2.88E-04 |
| ABC transporters, general | 4.58E-04 |
| Galactose metabolism | 7.13E-04 |
| Butanoate metabolism | 8.94E-04 |
| Fatty acid biosynthesis | 9.57E-04 |
| Alkaloid biosynthesis II | 1.15E-03 |
| Up-regulated genes | |
| Cell cycle | 6.57E-12 |
| Focal adhesion | 1.51E-09 |
| Tight junction | 1.01E-08 |
| Pyrimidine metabolism | 1.38E-08 |
| Regulation of actin cytoskeleton | 1.18E-07 |
| Pancreatic cancer | 8.04E-07 |
| Adherens junction | 1.25E-06 |
| Amino sugars metabolism | 2.81E-06 |
| MAPK signaling pathway | 1.36E-05 |
| Ribosome | 3.69E-05 |
| Leukocyte transendothelial migration | 8.21E-05 |
| Proteasome | 9.34E-05 |
| Huntington disease | 1.26E-04 |
| B cell receptor signaling pathway | 1.61E-04 |
| Chronic myeloid leukemia | 3.16E-04 |
| Antigen processing and presentation | 4.30E-04 |
| Gap junction | 5.37E-04 |
| Glioma | 5.82E-04 |
| Aminoacyl-tRNA biosynthesis | 8.98E-04 |
| Apoptosis | 9.30E-04 |