Table 3.

Local maxima within areas of significant differences in the magnitude of longitudinal changes in rCBF between APOE ε4 positive and negative groups. Coordinates are in stereotactic space and Brodmann areas are in parentheses.

Decreases in Resting rCBF
	Coordinate
Region	Side	x	y	z	T-value	p_uncorrected	Number of voxels	Percentage change from baseline	Baseline rcbf (ml/100g/min)
Region	Side	x	y	z	T-value	p_uncorrected	Number of voxels	Percentage change from baseline	ε4+ve	ε4 −ve
APOE ε4 POSITIVE > APOE ε4 NEGATIVE
Orbitofrontal cortex (47)	R	46	36	−12	3.64	<0.001	162	−4%	86.18 (5.2)^*	81.80 (4.6)
Middle frontal gyrus (10)	L	−42	48	−8	3.90	<0.001	636¹	−6%	75.96 (4.1)^*	71.42 (4.9)
Inferior frontal gyrus (47)	L	−40	22	−12	3.56	<0.001	636¹	−6%	95.75 (5.7)^*	88.06 (7.1)
Superior parietal cortex (7)	R	46	−66	50	3.21	0.001	136²	−6%	77.43 (4.6)^*	71.49 (5.5)
Angular gyrus (39)	R	42	−68	34	2.90	0.002	136²	−3%	89.03 (5.7)^*	81.39 (5.4)
Brainstem	R	2	−30	−8	3.90	<0.001	327	−2%	80.56 (8.1)^†	76.49 (5.7)
Middle temporal gyrus (20)	L	−40	−24	−12	3.93	<0.001	455	−2%	70.49 (7.8)^*	64.68 (4.3)
Inferior temporal cortex (20)^¶	R	60	−36	−28	3.50	<0.001	62	−2%	78.23 (6.2)^*	72.96 (4.6)
Superior temporal gyrus (22)^§	L	−64	−8	0	3.37	0.001	57	−5%	73.11 (4.4)^*	67.15 (4.6)

*Increases in Resting rCBF*

APOE ε4 POSITIVE > APOE ε4 NEGATIVE

Insula	R	32	−2	16	3.71	0.000	56	+5%	67.95 (5.8)^‡	65.15 (5.1)

Denotes local maxima contained within the same cluster

Each voxel represents 2mm x 2mm x 2mm tissue volume

^¶

Volume correction was not performed on this region due to registration errors

^§

Differences in rCBF in this region were not statistically significant after correcting for total tissue volume

p<0.001

^†

p<0.007

^‡

p=0.02.

Baseline rCBF values in regions showing longitudinal changes are presented as Mean (S.D.)