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. Author manuscript; available in PMC: 2011 Mar 23.
Published in final edited form as: Biochemistry. 2010 Mar 23;49(11):2475–2482. doi: 10.1021/bi901457e

Table 3.

The summary of loop conformations and observed ligands in crystal structures

High salt unliganded structures Low salt co-crystallization
structures
Crystals V3Lhs V3Fhs V3Yhs V3Ths V3L+
dUMP		 V3F+
FdUMP		 V3Y+
FdUMP
Ligand
present		 Leu3 no no no no FdUMP no
Loop180–198 inactive inactive inactive inactive inactive active active
Loop109–130 New
conformation		 New
conformation		 disordered disordered disordered Active
conformation		 Active
conformation
Polyalanine yes yes yes yes no no no
Space group P3121 P3121 P3121 P3121 P3121 C2 C2
Resolution 1.56 1.75 1.86 2.05 3.0 2.75 2.75