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. Author manuscript; available in PMC: 2010 Apr 19.

Published in final edited form as: Mol Ther. 2008 Sep 2;16(11):1865–1872. doi: 10.1038/mt.2008.184

Differential cell killing assay of PVS-RIPO. (a) Assays measuring differential cell killing of the control lot (L0603006; top panel) and xenograft passaged lot (022208; bottom panel) in HTB-14 cells (●) and HEK-293 cells () yielded similar results. (b) C values refer to the virus titer at half maximal cell killing; ED₅₀ values represent virus titers at 50% cell killing. C and ED₅₀ values were unchanged upon PVS-RIPO xenograft passage.

Inline graphic — Differential cell killing assay of PVS-RIPO. (a) Assays measuring differential cell killing of the control lot (L0603006; top panel) and xenograft passaged lot (022208; bottom panel) in HTB-14 cells (●) and HEK-293 cells () yielded similar results. (b) C values refer to the virus titer at half maximal cell killing; ED₅₀ values represent virus titers at 50% cell killing. C and ED₅₀ values were unchanged upon PVS-RIPO xenograft passage.