Figure 1.
Representative spinal cord sections from each condition illustrating degree of inflammation (sections A-D: all animals viral inoculated, section E: uninfected control, H & E stain-4× magnification). Subjects in the female/unstressed condition (section A) exhibited significantly less non-suppurative meningitis (arrows) and parenchymal inflammation/lymphocyte/microglia accumulation and perivascular cuffing (indicated by round-end pointers) compared to the female/stressed (section B), male/unstressed (section C), and male/stressed (section D) conditions. All infected conditions (sections A-D) had evidence of meningitis and inflammation compared to no lesions present in a section taken from an uninfected/unstressed age-matched comparison (section E).