Table 3.
Antiplasmodial Activity of Compounds 1–13
| Compound | D6-clone | W2-clone | cytotoxicity | ||
|---|---|---|---|---|---|
| IC50 ng/mL | S.I. | IC50 ng/mL | S. I. | IC50 ng/mL | |
| 1 | 750 | 2.0 | 600 | 2.5 | 1500 |
| 2 | 2300 | >2.1 | 2300 | >2.1 | NC |
| 3 | NA | - | NA | - | NC |
| 4 | 740 | 4.5 | 820 | 4.0 | 3300 |
| 5 | NA | - | NA | - | NC |
| 6 | 43 | 22.1 | 32 | 29.7 | 950 |
| 7 | 170 | 17.6 | 130 | 23.1 | 3000 |
| 8 | NA | - | NA | - | NC |
| 9 | 97 | 10.3 | 84 | 11.9 | 1000 |
| 10 | 900 | 5.3 | 670 | 7.1 | 4760 |
| 11 | 300 | 12.3 | 200 | 18.5 | 3700 |
| 12 | 250 | 6.8 | 190 | 8.9 | 1700 |
| 13 | NA | - | NA | - | NC |
| chloroquinea | 10 | 100 | NC | ||
| artemisinina | 4.7 | 3.8 | NC | ||
a
Positive controls
NC not cytotoxic at the highest dose (4760 ng/mL) tested
NA not active at the highest dose (4760 ng/mL) tested
S. I. (selectivity index) = IC50 for antiplasmodial activity/IC50 for cytotoxicity