Table 1.
Clinical characteristics of patients.
| Variables | HCC Cohort (N = 47) |
Nontumoral HCC cohort (N = 44) |
Tumor HCC cohort (N = 43) |
Control liver cohort (metastatic liver tumors, N = 8) |
|---|---|---|---|---|
| Age | 66.5 ± 7.8 | 66.4 ± 7.9 | 66.5 ± 7.9 | 60.0 ± 13.5 |
| Gender | ||||
| Male | 35 (74.4%) | 32 (72.7%) | 32 (74.4%) | 4 (50.0%) |
| Female | 12 (25.5%) | 12 (27.3%) | 11 (25.6%) | 4 (50.0%) |
| Viral infection status | ||||
| HBV infection | - | - | - | - |
| HCV infection | + | + | + | - |
| Liver resection procedure | ||||
| Lobular/extended lobular | 5 | 5 | 5 | N/A |
| Segmental/partial | 42 | 39 | 38 | |
| Platelet count (104/μl) | 12.9 ± 4.3 | 13.0 ± 4.2 | 12.8 ± 4.2 | 19.3+3.6* |
| Alanine aminotransferase (IU/l) | 51.0 ± 31.7 | 51.0 ± 32.0 | 51.7 ± 33.1 | 19.7+7.7* |
| Total bilirubin (mg/dl) | 0.80 ± 0.34 | 0.76 ± 0.30 | 0.80 ± 0.35 | 0.85+0.37 |
| Prothrombin time (%) | 78.3 ± 13.1 | 78.3 ± 12.9 | 78.1 ± 13.3 | 91.1+14.5 |
| Indocyanine green (%) | 18.4 ± 8.3 | 18.5 ± 8.3 | 18.3 ± 8.4 | 11.0+5.3 |
| α-Fetoprotein (ng/ml) | 319 ± 924 | 339 ± 952 | 345 ± 962 | N/A |
| Tumor diameter (cm) | 2.90 ± 1.30 | 2.97 ± 1.35 | 2.95 ± 1.37 | N/A |
| Number of tumors | 1.30 ± 0.50 | 1.32 ± 0.52 | 1.30 ± 0.51 | N/A |
| Portal vein invasion | ||||
| Present | 5 (10.6%) | 5 (11.4%) | 5 (11.6%) | N/A |
| Absent | 42 (89.4%) | 39 (88.6%) | 38 (88.4%) | N/A |
| Tumor stage | ||||
| I | 9 (19.1%) | 9 (20.5%) | 8 (18.6%) | N/A |
| II | 25 (53.2%) | 23 (52.3%) | 24 (55.8%) | N/A |
| III | 12 (25.5%) | 11 (25.0%) | 10 (23.3%) | N/A |
| IV | 1 (2.1%) | 1 (2.3%) | 1 (2.3%) | N/A |
| Tumor differentiation | ||||
| Well differentiated | 8 (17.0%) | 8 (18.2%) | 6 (14.0%) | N/A |
| Moderately differentiated | 31 (66.0%) | 28 (63.6%) | 29 (67.4%) | N/A |
| Poorly differentiated | 8 (17.0%) | 8 (18.2%) | 8 (18.6%) | N/A |
| Fibrosis score | ||||
| F0 | 0 (0%) | 0 (0%) | 0 (0%) | 8 (100%)* |
| F1 | 3 (6.4%) | 3 (6.8%) | 3 (7.0%) | 0 (0%) |
| F2 | 6 (12.8%) | 5 (11.4%) | 6 (14.0%) | 0 (0%) |
| F3 | 14 (29.8%) | 14 (31.8%) | 12 (27.9%) | 0 (0%) |
| F4 | 24 (51.1%) | 22 (50.0%) | 22 (51.2%) | 0 (0%) |
Data shown are mean ± standard deviation. N/A, data is not available. Asterisk(*) denotes statistical difference from other groups (ANOVA, p < 0.05).