Table 3.
Geometric means for antibody potency and antibody needed for 1:8 opsonization index (Elderly, N = 33; Adults, N = 24)
| Serotype | Age | Pre-Antibody potency (OT/[IgG]) | Post-Antibody potency (OT/[IgG]) | Pre-Antibody needed for 1:8 opsonization index (ng/ml) | Post-Antibody needed for 1:8 opsonization index (ng/ml) | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| GMP | 95% CI | Sig | GMP | 95% CI | Sig | GMI | Sig | GMI | Sig | ||
| 4 | Adult | 42 | 16-111 | NS | 633 | 372-1076 | P < 0.05 | 191.4 | NS | 12.6 | P < 0.05 |
| Elderly | 37 | 18-73 | 171 | 77-378 | 218.6 | 46.7 | |||||
| 6B | Adult | 343 | 102-1153 | NS | 1349 | 743-2451 | NS | 23.3 | NS | 5.9 | NS |
| Elderly | 150 | 57-392 | 710 | 418-1209 | 53.5 | 11.3 | |||||
| 9V | Adult | 458 | 145-1448 | NS | 1112 | 554-2233 | NS | 17.5 | NS | 7.2 | NS |
| Elderly | 324 | 126-834 | 813 | 466-1417 | 24.7 | 9.8 | |||||
| 14a | Adult | 63 | 23-172 | NS | 423 | 202-886 | NS | 126.1 | NS | 18.9 | NS |
| Elderly | 248 | 71-860 | 426 | 211-859 | 32.3 | 18.8 | |||||
| 18C | Adult | 641 | 242-1699 | NS | 1440 | 951-2182 | NS | 12.5 | NS | 5.6 | NS |
| Elderly | 286 | 121-677 | 990 | 655-1497 | 28.0 | 8.1 | |||||
| 19A | Adult | ND | ND | ND | ND | ND | ND | ND | ND | ||
| Elderly | ND | ND | ND | ||||||||
| 19F | Adult | 12 | 5-30 | NS | 276 | 195-391 | P < 0.05 | 653.2 | NS | 29.0 | P < 0.05 |
| Elderly | 15 | 7-31 | 165 | 128-212 | 535.7 | 48.5 | |||||
| 23F | Adult | 789 | 309-2012 | NS | 982 | 650-1482 | P < 0.05 | 10.1 | NS | 8.1 | P < 0.05 |
| Elderly | 386 | 170-879 | 571 | 396-824 | 20.7 | 14.0 | |||||
| 6A | Adult | 32 | 11-96 | P < 0.05 | 888 | 444-1774 | P < 0.05 | 249.1 | P < 0.05 | 9.0 | P < 0.05 |
| Elderly | 5 | 3-11 | 61 | 28-134 | 1486.5 | 131.3 | |||||
pre vs post P < 0.05
a For Pn 14 OPKA was done in a limited patients due to lack of sera {Adults (N = 10), Elderly (N = 20)}.