Table 4.
Different effect model of the recurrent MI events in the LIPID study
| Risk factor | First MI event | Second MI event | Wald test† | ||||
|---|---|---|---|---|---|---|---|
| HR | 95% CI | P-value | HR | 95% CI | P-value | ||
| Age (year) | 1.02 | 1.01 - 1.03 | <0.001 | 1.04 | 1.01 - 1.06 | 0.007 | 0.14 |
| Smoking status | |||||||
| Non-smoker | 1.0 | 1.0 | |||||
| Current smoker | 1.49 | 1.20 - 1.85 | <0.001 | 1.71 | 0.94 - 3.12 | 0.079 | 0.63 |
| Total cholesterol | 1.18 | 1.08 - 1.28 | <0.001 | 1.34 | 1.08 - 1.66 | 0.007 | 0.21 |
| HDL cholesterol | 0.41 | 0.29 - 0.59 | <0.001 | 0.17 | 0.06 - 0.47 | 0.001 | 0.076 |
| Qualifying event for ACS | |||||||
| Unstable angina | 1.0 | 1.0 | |||||
| Single MI | 1.27 | 1.06 - 1.53 | 0.011 | 1.44 | 0.81 - 2.54 | 0.21 | 0.66 |
| Multiple MI | 1.92 | 1.54 - 2.40 | <0.001 | 2.46 | 1.34 - 4.54 | 0.004 | 0.39 |
| Revascularization | |||||||
| Never | 1.0 | 1.0 | |||||
| Before ACS | 1.54 | 1.23 - 1.92 | <0.001 | 2.02 | 1.10 - 3.74 | 0.024 | 0.34 |
| Since ACS | 0.70 | 0.58 - 0.85 | <0.001 | 0.65 | 0.36 - 1.16 | 0.14 | 0.76 |
| History of stroke | |||||||
| No | 1.0 | 1.0 | |||||
| Yes | 1.50 | 1.12 - 2.00 | 0.006 | 1.31 | 0.57 - 3.04 | 0.53 | 0.75 |
| Diabetes mellitus | |||||||
| No | 1.0 | 1.0 | |||||
| Yes | 1.40 | 1.12 - 1.75 | 0.003 | 1.14 | 0.58 - 2.23 | 0.70 | 0.53 |
| Angina grade | |||||||
| CCVS < III | 1.0 | 1.0 | |||||
| CCVS ≥ III | 1.44 | 1.16 - 1.80 | 0.001 | 1.48 | 0.83 - 2.65 | 0.18 | 0.91 |
| Treatment | |||||||
| Placebo | 1.0 | 1.0 | |||||
| Pravastatin | 0.72 | 0.62 - 0.83 | <0.001 | 0.66 | 0.43 - 0.99 | 0.047 | 0.67 |
† P-value for Wald test. ACS = Acute Coronary Syndrome; CCVS = Canadian Cardiovascular Society Class of angina; HDL = High Density Lipoprotein; MI = Myocardial Infarction.