TABLE.
Summary of Transplantation Results
| Age at Transplantation | Weight, kg | Cells Transplanted | Graft Site | Graft Detected | Graft Size, mm | GUSB Expression | Time Point of Death | |
|---|---|---|---|---|---|---|---|---|
| Dog 1 | 23 days | 1.2 | GUSB-OB-cNPC-MPIO* | Left CN/Th† | Yes | 1.1 | Positive | 8 days |
| Dog 2 | 23 days | 1.3 | GUSB-OB-cNPC-MPIO | Left CN/Th | Yes | 0.54 | Negative | 4 weeks |
| Dog 3 | 23 days | 1.4 | GUSB-OB-cNPC‡ | Left CN/Th | Yes | 0.84 | Positive | 4 weeks |
| Dog 4 | 23 days | 1.3 | GUSB-OB-cNPC | Left CN/Th | No | NA§ | NA | 4 weeks |
| Dog 5 | 5 months | 8.5 | OB-cNPC-MPIO|| | Right cortex | Yes | NE¶ | NA | 2 weeks |
| Dog 6 | 5 months | 8.5 | OB-cNPC-MPIO | Right cortex | Yes | NE | NA | 2 weeks |
| Dog 7 | 5 months | 7.8 | OB-cNPC-MPIO | Right cortex | Yes | NE | NA | 8 weeks |
| Dog 8 | 5 months | 7.4 | OB-cNPC-MPIO | Right cortex | Yes | NE | NA | 8 weeks |
GUSB-OB-cNPC-MPIO, canine olfactory-bulb NPCs transduced with β-glucuronidase vector and labeled with MPIO.
CN/Th, caudate nucleus/thalamus.
GUSB-OB-cNPC, canine olfactory-bulb NPCs transduced with β-glucuronidase vector.
NA, not applicable.
OB-cNPC-MPIO, canine olfactory-bulb NPCs labeled with MPIOs.
NE, not evaluated.