Table 2.
Degrees of Freedom and F-values for the Tat Effectsa Conducted for Each of the Three Brain Regions: 3-way MANOVAb Analysis on Percent Chemokine/Cytokine Levels.
| Dependent Variable | DF | Cortex | Cerebellum | Spinal Cord |
|---|---|---|---|---|
| IL-1β | (1, 47) | 103.27*** | 5.18* | 29.64*** |
| GM-CSF | (1, 47) | 76.27*** | 40.83*** | 28.37*** |
| IFN-γ | (1, 47) | 65.17*** | 1.85 | 6.26* |
| TNF-α | (1, 47) | 10.24** | 0.36 | 12.38** |
| IL-6 | (1, 47) | 20.35*** | 19.22*** | 13.97** |
| KC | (1, 47) | 42.12*** | 29.41*** | 12.66** |
| MIP-1α | (1, 47) | 207.32*** | 25.48*** | 15.94*** |
| RANTES | (1, 47) | 50.98*** | 33.01*** | 13.03** |
| EOTAXIN | (1, 47) | 57.30*** | 36.29*** | 65.63*** |
| MIP-1β | (1, 47) | 50.52*** | 15.44*** | 15.33*** |
| MCP-1 | (1, 47) | 81.07*** | 31.73*** | 13.93** |
| IL-9 | (1, 47) | 111.06*** | 23.50*** | 21.68*** |
p ≤ 0.05
p ≤ 0.01
p ≤ 0.001; DF = degrees of freedom
No other significant effects were revealed.
MANOVA: [2 (±Tat) × 2 (±Gp120) × 2 (±Morphine)] for the 12 chemokines/cytokines in each brain region.