Skip to main content
. Author manuscript; available in PMC: 2011 Mar 15.
Published in final edited form as: J Immunol. 2010 Feb 8;184(6):2793–2804. doi: 10.4049/jimmunol.0902846

Figure 7. A model depicting the regulatory network that controls Bcl-xL expression in preselection DP thymocytes.

Figure 7

Bcl-xL is necessary for the survival of small pre-selection DP thymocytes during αβT cell development. c-Myb, RORγt and TCF-1 are all required to efficiently up-regulate Bcl-xL expression in DP thymocytes. RORγt also promotes the large to small pre-selection DP transition. Increased c-Myb expression in small pre-selection DP thymocytes promotes the expression of Bcl-xL by a genetic pathway independent of RORγt and TCF-1. Expression of RORγt appears to be TCF-1 dependent.