Table 2.

Efficiency, resolution and total run time data gathered from the D-optimal experimental design run order for multivariate optimization of surfactant based monolithic columns

Monolithic Column No.	Variable factors					Responses
						Alkylbenzenes			Alkyl phenyl ketones
	EDMA (%)	AAUA (%)	1-propanol (%)	1,4-buta nediol (%)	Water (%)	Rs(avg)a	tRb (min)	Navgc (plates/m)	Rs(avg)a	tRb (min)	Navgc (plates/m)
1	21.3	7.0	60.0	0	11.2	2.2	18.8	73,000	3.5	22.6	72,400
2	19.9	1.8	60.0	5.8	12.0	0.7	4.8	5,000	1.0	6.4	4,500
3	18.5	7.0	60.0	2.0	12.0	2.6	15.4	92,100	3.1	18.9	88,900
4	21.3	7.0	69.2	0	2.0	1.0	6.6	5,400	1.0	9.3	5,300
5	19.9	1.8	63.8	12	2.0	d	3.4	e	d	5.1	e
6	21.3	4.2	60.0	12	2.0	0.6	8.9	5,400	1.0	6.8	5,100
7	21.3	1.8	74.0	0.2	2.2	d	1.0	e	d	0.8	e
8	18.5	1.8	67.2	0	12	0.6	6.0	6,000	0.9	5.7	5,700
9	19.2	2.9	69.6	2.1	5.7	d	1.2	e	d	0.8	e
10	18.5	7.0	60.0	2.0	12.0	2.4	14.8	108,000	3.3	17.0	98,100
11	19.9	1.8	63.8	12	2.0	d	1.4	e	d	0.9	e
12	21.3	1.8	74.0	0.2	2.2	d	1.1	e	0.1	0.9	e
13	21.3	4.2	60.0	12	2.0	0.4	3.3	3,000	0.3	4.3	2,000
14	18.5	7.0	72.0	0	2.0	0.8	5.9	7,100	0.8	6.2	6,600
15	19.9	3.6	74.0	0	2.0	d	1.4	e	d	1.0	e
16	18.5	7.0	60.0	12	2.0	0.8	3.4	3,700	1.1	4.4	3,300
17	21.3	4.0	62.2	0	12.0	1.7	9.7	25,100	3.0	16.4	22,700
18	19.2	2.9	64.4	3.9	9.1	0.6	3.5	4,800	0.7	4.2	4,700
19	19.2	4.2	62.6	8.1	5.4	0.4	2.5	7,400	0.6	3.3	6,800
20	18.5	1.8	60.0	12	7.2	0.5	3.8	4,600	0.6	4.1	4,200
21	18.5	1.8	69.6	7.6	2.0	d	1.5	--	d	0.6	e
22	18.5	7.0	67.0	0	7.0	2.1	14.3	52,300	3.3	18.1	51,200
23	18.5	7.0	66.0	6.0	2.0	0.5	2.4	4,400	0.6	3.0	3,200
24	21.3	7.0	69.2	0	2.0	0.9	7.7	6,200	1.2	9.0	5,600
25	19.8	7.0	62.9	2.9	6.9	1.8	7.2	29,000	2.5	8.9	26,400

^aRs_(avg) is the average resolution of the five ABs or six APKs.

^bt_R is the retention time of the last peak of ABs or APKs.

^cN_avg is the average efficiency taken from the first four peaks of the ABs or APKs;

^eNo efficiency reported due to zero resolution.