Table 3.

Greater Areas of Activity in DRD4.L Group Compared With the Control Group

Region	BA	Peak Z-score	TLRC
DRD4.L > Controls
Prepriming
L OFC*	47	3.17	−42, 43, −5
L subcallosal gyrus	25	3.10	−10, 19, −15
L IFG	47	2.92	−36, 29, −15
R putamen	–	2.79	24, 11, −7
L OFC*	47	2.54	−14, 23, −15
R insula	13	2.41	28, 17, −7
R OFC	11	2.26	40, 45, −13
R OFC	11	2.21	12, 25, −15
R VTA/midbrain	–	1.90	10, −17, −15
Postpriming
None
Controls > DRD4.L
Prepriming
R medial frontal gyrus	10	3.65	20, 43, −1
L ACG	32	3.38	16, 33, 7
R caudate	–	3.05	22, 21, 5
R ACG	32	2.90	16, 41, −1
L caudate	–	2.66	−18, 27, 1
R IFG	11	1.78	26, 31, −25
Postpriming
R IFG	47	3.93	23, 31, −11
L OFC	11	3.64	−24, 35, −13
L caudate	–	3.58	22 27 −7
R globus pallidus	–	3.57	20, −13, −5
L thalamus	–	3.35	−10, −3, −13
R VTA/midbrain	–	3.30	14, −9, −9
R putamen	–	3.21	−10, 5, −9
R ACG	32	2.99	18, 33, −11
L VTA/midbrain	–	2.87	−6, −19, −9
L putamen	–	2.80	−24, 9, −7
R thalamus	–	2.70	18, −5, 13

L, left; R, right; OFC, orbitofrontal cortex; IFG, inferior frontal gyrus; VTA, ventral tegmental area; ACG, anterior cingulate gyrus.

Without priming, the DRD4.L subjects had greater BOLD response in all of the ROIs compared to the controls (p < 0.05). None of these structures was greater in the DRD4.L subjects after priming. Maximum loci of activation are listed for each substrate as anatomical labels, Brodmann area (BA) corresponding peak z-score, and Talairach (TLRC) co-ordinates corresponding of greater BOLD response in the risk allele group compared with the nonrisk allele group.

^*Foci of peak activation (i.e., L OFC) that overlap with OPRM1.G individuals.