Table 4.

Greater Areas of Activity in OPRM1.G Group Compared With the Control Group

Region	BA	Peak Z-score	TLRC
OPRM1.G > Controls
Prepriming
L ACG	25	2.44	−1, 23, −9
L OFC*	11	2.41	−26, 35, −13
L VS/NAc	–	2.27	−30, 9, −11
L OFC*	11	2.25	−40, 37, −13
R IFG	47	2.24	30, 21, −13
R VS/NAc	–	2.17	28, 7, −13
R IFG	47	2.15	28, 19, −13
R ACG	32	1.99	10, 29, −11
Postpriming
L IFG	47	2.36	−28, 33, −7
L globus pallidus	–	2.13	−18, 1, −5
L ACG	24	2.10	−12, 27, −3
R OFC	11	2.08	15, 55, −17
L ACG	25	2.04	−2, 11, −5
L OFC	11	2.01	−16, 53, −17
R claustrum	–	1.88	30, 11, −7
R putamen	–	1.87	18, 15, −7
R putamen	–	1.82	20, 17, −7
R IFG	47	1.81	34, 23, −9
R medial frontal gyrus	11	1.72	4, 47, −11
Controls > OPRM1.G
Prepriming
R middle frontal gyrus	10	3.83	30, 51, −1
R ACG	32	3.03	16, 39, 1
R globus pallidus	–	2.47	18, −5, 5
R caudate	–	2.46	22, 19, 7
L thalamus	–	2.04	−18, −9, 9
R IFG	47	1.94	16, 15, −23
L middle frontal gyrus	10	1.86	−22, 51, −1
R IFG	11	1.80	26, 31, −25
L VTA/midbrain	–	1.65	−15, −16, −13
Postpriming
R IFG	47	3.00	18, 13, −23
L IFG	47	2.22	−16, 15, −23
L IFG	11	2.13	−24, 29, −25
R medial frontal gyrus	9	1.89	6, 51, 23
L medial frontal gyrus	10	1.83	−18, 49, −3
L medial frontal gyrus	10	1.70	−12, 47, 1
L medial frontal gyrus	10	1.70	−6, 55, 15
R IFG	47	1.67	26, 25, −23

L, left; R, right; ACG, anterior cingulate gyrus; OFC, orbitofrontal cortex; VS/NAc, ventral striatum/nucleus accumbens; IFG, inferior frontal gyrus; VTA, ventral tegmental area.

The OPRM1.G subjects had greater BOLD response in all of the ROIs (except the VTA) before and after priming compared with the controls. Maximum loci of activation are listed for each substrate as anatomical labels, corresponding Brodmann area (BA), peak z-score and Talairach (TLRC) co-ordinates of greater BOLD response in the risk allele group compared with the nonrisk allele group (p < 0.05).

^*Foci of activation (i.e., L OFC) that overlap with DRD4.L individuals.