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Results of comparative anticancer evaluation of narciclasine and related isocarbostryrils in the NCI sixty cell line screen
| compound | mean GI50 |
compare correlation coefficient |
|---|---|---|
| µM | ||
| narciclasine (44) | 0.016 | 0.90 |
| 7-deoxynarciclasine (45) | 0.15 | 0.90 |
| trans-dihydronarciclasine (49) | 0.013 | 0.92 |
| 7-Deoxy-trans-dihydronarciclasine (50) | 0.068 | 0.89 |
| pancratistatin (51) | 0.091 | 1 |
| cis-dihydronarciclasine (77) | 3.8 | < 0.6 |
| 7-deoxy-cis-dihydronarciclasine (112) | 95.5 | < 0.6 |
| isonarciclasine (78) | 11.8 | < 0.6 |
