Skip to main content
. Author manuscript; available in PMC: 2010 Apr 19.
Published in final edited form as: Cell. 2009 Mar 6;136(5):952–963. doi: 10.1016/j.cell.2008.12.039

Figure 5. Triplet genetic motifs (TGMs) from the signaling E-MAP.

Figure 5

a) A schematic of the four types of triplet genetic motifs: all three positive (Type I); two positive, one negative (Type II); one positive, two negative (Type III); and all three negative (Type IV). b) A network diagram of all TGMs involving three kinases using highly negative (S ≤ −2.5) and positive (S ≥ 2.0) genetic interactions. The motifs were connected if they shared one or two nodes; blue and yellow edges correspond to negative and positive genetic interactions, respectively. The thickness of the edges is correlated with the strength of the genetic interaction. TGMs highlighted in grey are discussed in the text. c) Comparison of the ratio of the four types of TGMs that contain one or more kinase or phosphatase. The ratios are obtained by normalizing the number of genetic triplet motifs within each set (i.e. Types II, III, and IV) to the number of TGMs that are all positive (Type I). For a complete list of all TGMs, see Supplementary Table 5.