Figure 5. System dynamics in the presence of probiotics.
Health or disease states are predicted as parameter
is varied:
(red),
(green),
(blue),
(black), and
(dashed). The system is simulated in the bistable region, with initial pathogenic bacteria insult
cells/g, pathogenic bacteria growth rate
h
, and probiotic bacteria growth rate
h
. (A) Bacteria in lumen,
. (B) Probiotic bacteria in lumen,
. (C) Permeability,
. (D) Bacteria in blood/tissue,
. (E) Probiotic bacteria in blood/tissue,
. (F) Immune cells,
. (G) Total bacteria in lumen,
. (H) Product of luminal bacteria and permeability,
. (I) Difference between product in (H) and threshold,
.
