Table 2.
Genes that are upregulated by inosine in CSNs contralateral to cortical injury and in retinal ganglion cells undergoing axon regeneration in vivo
| Probe | Symbol | Definition | Fold induction |
|
|---|---|---|---|---|
| CSMNsa | RGCsb | |||
| ILMN_53325 | LOC498335 | (P) Small inducible cytokine B13 precursor (CXCL13) | 11.42 | 3.97 |
| ILMN_70335 | A2m | α-2-Macroglobulin | 4.10 | 2.36 |
| ILMN_62559 | Timp1 | Tissue inhibitor of metalloproteinase 1 | 3.74 | 13.00 |
| ILMN_51277 | LOC305633 | (P) Antxr2 protein | 3.13 | 4.82 |
| ILMN_60046 | Serping1 | Serine (or cysteine) peptidase inhibitor, clade G, member 1 | 2.93 | 4.63 |
| ILMN_48088 | Ifitm3 | (P) Interferon induced transmembrane protein 3 | 2.74 | 1.99 |
| ILMN_55502 | C1qg | Complement component 1, q subcomponent, γ polypeptide | 2.73 | 2.62 |
| ILMN_53575 | Mt1a | Metallothionein | 2.69 | 6.02 |
| ILMN_58058 | Lcp1 | (P) Lymphocyte cytosolic protein 1 | 2.68 | 2.07 |
| ILMN_60003 | Cd68 | (P) CD68 antigen | 2.62 | 3.34 |
| ILMN_60037 | Lgals3bp | Lectin, galactoside-binding, soluble, 3 binding protein | 2.60 | 3.03 |
| ILMN_68224 | Gfap | (P) Glial fibrillary acidic protein | 2.46 | 5.10 |
| ILMN_57422 | Serpinb1a | (P) Serine (or cysteine) proteinase inhibitor, clade B, member 1a | 2.41 | 2.93 |
| ILMN_55731 | Bzrp | Benzodiazepine receptor, peripheral | 2.38 | 2.43 |
| ILMN_47707 | Aif1 | Allograft inflammatory factor 1 | 2.33 | 2.33 |
| ILMN_69642 | Arpc1b | Actin related protein 2/3 complex, subunit 1B | 2.31 | 2.48 |
| ILMN_59412 | Emp3 | Epithelial membrane protein 3 | 2.20 | 2.16 |
| ILMN_48069 | Crabp2 | Cellular retinoic acid binding protein 2 | 2.12 | 8.63 |
| ILMN_67382 | Cd63 | CD63 antigen (Cd63) | 2.10 | 3.03 |
| ILMN_55706 | C1s | Complement component 1, s subcomponent | 2.03 | 2.03 |
| ILMN_67686 | Ms4a6b | Membrane-spanning 4-domains, subfamily A, member 6B | 2.03 | 2.22 |
| ILMN_61063 | Rhoc | (P) Ras homolog gene family, member C | 2.02 | 2.71 |
| ILMN_54242 | Vim | Vimentin | 1.96 | 2.69 |
| ILMN_55431 | Rnaset2 | (P) Ribonuclease T2 | 1.88 | 1.79 |
| ILMN_62651 | Eif4ebp1 | Eukaryotic translation initiation factor 4E binding protein 1 | 1.86 | 2.39 |
| ILMN_58496 | C1qa | Complement component 1, q subcomponent, α polypeptide | 1.84 | 1.66 |
| ILMN_53085 | Irf1 | Interferon regulatory factor 1 | 1.83 | 1.61 |
| ILMN_62100 | Ftl1 | Ferritin light chain 1 | 1.74 | 2.28 |
| ILMN_59774 | Ppp1r14b | Protein phosphatase 1, regulatory (inhibitor) subunit 14B | 1.74 | 3.36 |
| ILMN_59161 | Npc2 | Niemann Pick type C2 | 1.73 | 2.38 |
(P), Predicted.
aFold change over and above the effect of inosine of decreasing stroke-induced changes.
bBased on comparison between active regeneration state (induced by macrophage-derived factors) and normal control RGCs collected by fluorescence-activated cell sorting. From Fischer et al. (2004) (supplemental data, available at www.jneurosci.org as supplemental material).