Table 3. MPO deficiency enhances endotoxemia-induced increases in cysteinyl LTs.

LT plasma levels were analyzed 24 h after endotoxemia induction. Results represent mean ± SEM derived from at least four animals per group. *p < 0.05 MPO-KO vs. wild-type, +p < 0.05 control wild-type vs. LPS treated wild-type, #p < 0.05 control MPO-KO vs. LPS treated MPO-KO. Plasma levels of LTA4 were under detection limits in both wild-type and MPO-KO mice. Limits of quantification are in Supplement Table 1.

Plasma concentration (nM)	Control WT	Control MPO-KO	LPS WT	LPS MPO-KO
Leukotriene B4 (LTB4)	0.4 ± 0.5	0.5 ± 0.7	16.2 ± 6.8	20.6 ± 4.3
Leukotriene C4 (LTC4)	2.1 ± 1.4	9.9 ± 0.6 *	9.2 ± 1.4 +	16.3 ± 1.8 *#
Leukotriene D4 (LTD4)	3.3 ± 2.1	4.1 ± 1.9	6.6 ± 1.6	24.9 ± 4.9 *#
Leukotriene E4 (LTE4)	0.9 ± 0.3	4.2 ± 0.8 *	3.1 ± 0.6 +	14.3 ± 1.5 *#
N-acetyl-leukotriene E4 (LTE4-NA)	0.1 ± 0.0	0.1 ± 0.0	6.4 ± 0.5 +	14.6 ± 4.2 *#