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. Author manuscript; available in PMC: 2010 Apr 20.
Published in final edited form as: J Neurochem. 2010 Jan 7;112(6):1593–1604. doi: 10.1111/j.1471-4159.2010.06568.x

Fig. 2.

Fig. 2

LRRK2 binds to MKK7 but not MKK4 and activates the JNK pathway. (A) LRRK2 co-immunoprecipitates with MKK7 but not MKK4 in HEK-293FT cells. (B) LRRK2 kinase and COR domains are essential and sufficient for its interaction with MKK7. (C) Dominant negative K82A mutation in MKK7 reduces MKK7 binding to LRRK2. All experiments have been performed three times.