Table 1. IgG responses to prostate-associated proteins are elicited after short-term ADT.
Sera were collected from 20 patients immediately prior to and after 1 and/or 3 months of treatment with androgen deprivation (as shown). Sera from the post-treatment time point(s) were screened for IgG in SEREX studies and the number of immunoreactive plaques/200,000 screened plaques is shown (primary). These plaques were then screened with sera obtained prior to androgen deprivation, and the number of phage to which IgG responses were elicited or augmented after treatment (Pre −/Post +) is shown, as well as the sequence identification of the encoded proteins.
| Subject | Sera Screened | Immunoreactive Plaques | Sequence Identification | |||
|---|---|---|---|---|---|---|
| Baseline | 1 month | 3 month | Primary | Pre − /Post+ | ||
| 1 | x | x | x | 57 | 1 | Telomere-associated ADP-ribosyl transferase |
| 2 | x | x | 51 | 6 | Actinin, alpha 2 | |
| ElaC homolog 2 | ||||||
| Caldesmon 1 | ||||||
| A kinase anchor protein | ||||||
| Cell division cycle 73, Paf1/RNA pol II complex component | ||||||
| Tankyrase, TRF1-interacting ankyrin-related ADP-ribose pol 2 | ||||||
| 3 | x | x | 21 | 0 | ||
| 4 | x | x | 58 | 0 | ||
| 5 | x | 32 | 0 | |||
| 6 | x | x | 31 | 0 | ||
| 7 | x | x | 16 | 0 | ||
| 8 | x | x | 14 | 0 | ||
| 9 | x | x | 13 | 0 | ||
| 10 | x | x | 38 | 6 | Fms - related tyrosine kinase 3 ligand | |
| Palmitoylated 5 membrane protein | ||||||
| Chromosome 14 gene contig. | ||||||
| Clone RP11-421D6 on chromosome 13 | ||||||
| TSC22 domain family member 1 | ||||||
| Transgelin transcript variant 2 | ||||||
| 11 | x | x | 21 | 0 | ||
| 12 | x | x | 37 | 2 | NSFL1(p97) cofactor (p47) NSFL1C, transcript variant 3 | |
| Chromosome 16 gene contig. | ||||||
| 13 | x | x | 30 | 1 | Paxillin | |
| 14 | x | x | 37 | 4 | Chromosome 6 gene contig. | |
| RNA polymerase II | ||||||
| Amyloid beta precursor protein binding protein 1 | ||||||
| Rho guanine nucleotide exchange factor 12 | ||||||
| 15 | x | x | 36 | 4 | Chromosome 1 gene contig. | |
| Chromosome 5 gene contig. | ||||||
| Regulator of chromosome condensation 2 | ||||||
| Chromosome 16 gene contig. | ||||||
| 16 | x | x | 34 | 0 | ||
| 17 | x | x | 33 | 0 | ||
| 18 | x | x | 84 | 1 | Glucosamine-Phosphate N-acetyltransferase 1 | |
| 19 | x | x | 129 | 1 | Sorbitol dehydrogenase | |
| 20 | x | x | 63 | 5 | Chromosome 4 gene contig. | |
| Similar to laminin receptor 1 | ||||||
| Myosin heavy chain 11 | ||||||
| Metastasis associated lung adenocarcinoma transcript 1 | ||||||
| Sec 61 alpha subunit | ||||||