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. Author manuscript; available in PMC: 2011 May 1.
Published in final edited form as: Biochim Biophys Acta. 2010 Feb 20;1803(5):534–543. doi: 10.1016/j.bbamcr.2010.02.004

Fig. 4. Panel I. EM analysis of the CB after LMB treatment.

Fig. 4

A. Spermatids isolated from stages VII–VIII tubular fragments were incubated with vehicle (control), LMB or DRB for 3 and 6 h. Typical CB structure (red arrow). Abnormal compact CB (pink arrows). N, nuclear. Panel II. CB of spermatids from WT and GRTH−/− previously reported (7) are presented for comparative purposes. Green arrow: CB-wild type, Pink arrow: CB - null mice. Panel III. Diagram illustrates the relevance GRTH for the structural integrity of the CB in the spermatids of mouse testis. Distribution of GRTH/Ddx25 (red circle), MVH/Ddx4 (solid blue circle) and MIWI (blue-stripped circle) in cellular compartments of round spermatids; Nucleus (N), cytoplasm (C) and CB (green, hexagon). Abnormal compact CB noted in GRTH−/− mice and after treatment with inhibitor (LMB or DRB) compared with the CB in spermatids of wild type (stages VII–VIII).