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. Author manuscript; available in PMC: 2011 May 1.
Published in final edited form as: Biochim Biophys Acta. 2010 Feb 20;1803(5):534–543. doi: 10.1016/j.bbamcr.2010.02.004

Fig. 6. Postulated model of GRTH action in the CB of male germ cells.

Fig. 6

During spermatogenesis, specific RNA transcripts associated to GRTH in mRNP complexes are found in the nucleus of round spermatids. These GRTH-RNP complexes are transported from nucleus to cytoplasm (a) and the CB (b) via a CRM1-dependent export pathway. GRTH-RNP complexes are required to maintain CB filamentous-lobulated perinuclear structure (CB-EM image). GRTH does not directly interact with protein factors of si/mi/pi RNA pathway that might occur in the CB. We propose that specific messages associated with GRTH are presented to members of this system (RISC: RNA induced silencing complex- [decapping enzyme Dcp1a, MIWI, MVH, Dicer]) for either storage (noted as 1) or degradation (noted as 2). GRTH most probably dissociate from mRNA at the CB site during this process. Messages are transported by GRTH from CB to polyribosomes for translation.