Table 2.
Associations of the pooled sample with independent variables
| Grey matter density | Grey matter Volumes | |||||||
|---|---|---|---|---|---|---|---|---|
| Association of grey matter volumes with HSV1 exposure status | ||||||||
| MNI Coordinate | Region | Brodmann Area |
T | FDR corrected p | HSV1 Neg (cc) | HSV1 Pos (cc) | F (1, 39) |
p |
| 54 8 39 26 44 36 |
R Middle Frontal G R Superior Frontal G |
BA 9 | 5.60 4.74 |
0.026 0.036 |
4.79±0.52 | 4.34±0.54 | 6.96 | 0.012 |
| 62 −2 −2 | R Superior Temporal G | BA 22 | 4.37 | 0.048 | 0.14±0.02 | 0.12±0.03 | 4.97 | 0.032 |
| −6 66 4 | L Superior Frontal G | BA 10 | 4.34 | 0.048 | 0.30±0.05 | 0.28±0.05 | 1.31 | 0.26 |
| 8 6 50 | R Dorsal Ant Cingulate G | BA 32 | 4.17 | 0.056* | 0.14±0.02 | 0.13±0.02 | 4.55 | 0.039 |
| −2 10 34 | Left Ant Cingulate G | BA 24 | 4.03 | 0.060* | 0.21±0.02 | 0.19±0.03 | 7.79 | 0.008 |
| Association of grey matter volumes with MICB Genotypes | ||||||||
| MNI Coordinate | Region | Brodmann Area |
T | FDR corrected p | GG (cc) | AG (cc) | F (1, 39) |
p |
| −20 −38 58 | L Postcentral G | BA 3 | 5.73 | 0.031 | 0.97±0.14 | 0.91±0.16 | 1.59 | 0.22 |
| −6 16 54 | L Superior Frontal G | BA 8 | 5.30 | 0.031 | 0.57±0.11 | 0.56±0.11 | 0.05 | 0.83 |
| −18 −26 −8 | L Parahippocampal G | BA 28 | 5.16 | 0.031 | 0.43±0.06 | 0.41±0.05 | 1.81 | 0.19 |
| 4 −34 36 | L Dorsal Ant Cingulate G | BA 31 | 5.07 | 0.031 | 1.42±0.18 | 1.36±0.18 | 1.35 | 0.25 |
| −14 −64 34 | L Precuneus | BA 7 | 4.59 | 0.038 | 0.30±0.06 | 0.23±0.08 | 10.63 | 0.002 |
| −48 −30 34 | L Inferior Parietal Lobule | BA 40 | 4.59 | 0.038 | 0.21±0.06 | 0.16±0.05 | 6.28 | 0.017 |
| −4 −46 14 | L Ant Cerebellum Culmen | 4.52 | 0.038 | 0.79±0.12 | 0.74±0.13 | 1.22 | 0.28 | |
| −8 48 30 | L Medial Frontal G | BA 9 | 4.23 | 0.046 | 0.22±0.03 | 0.23±0.04 | 0.89 | 0.35 |
| −40 24 18 | L Inferior Frontal G | BA 45 | 4.19 | 0.048 | 0.13±0.04 | 0.09±0.05 | 6.12 | 0.018 |
| 24 −32 60 | R Postcentral G | BA 3 | 4.14 | 0.049 | 0.26±0.07 | 0.24±0.04 | 0.74 | 0.40 |
| Association of grey matter volumes with Gender | ||||||||
| MNI Coordinate | Region | Brodmann Area |
T | FDR corrected p | Female (cc) | Male (cc) | F (1, 39) |
p |
| −12 12 4 | L Caudate | 5.49 | 0.023 | 2.54±0.24 | 2.67±0.26 | 2.74 | 0.11 | |
| 62 −56 0 | R Middle Temporal G | BA 21 | 5.34 | 0.023 | 1.67±0.22 | 1.75±0.18 | 1.79 | 0.19 |
| −52 −74 −2 | L Inferior Temporal G | BA 37 | 4.74 | 0.023 | 0.84±0.10 | 0.87±0.09 | 0.83 | 0.37 |
| −26 −88 20 | L Cuneus | BA 19 | 4.51 | 0.026 | 1.14±0.19 | 1.17±0.14 | 0.21 | 0.65 |
| −2 −24 2 | L Thalamus | 4.04 | 0.040 | 0.79±0.12 | 0.76±0.08 | 1.25 | 0.27 | |
| 34 32 −10 | R Inferior Frontal G | BA 47 | 4.14 | 0.036 | 0.10±0.02 | 0.10±0.04 | 0.04 | 0.85 |
*
These regions are included here because we observed changes in cingulate gyrus in our previous publication (Prasad et al., 2007)