Table 4.
Grey matter density and volume across HSV1 serological status with and without MICB genotypes as an additional covariate within SZ group in a regression model with age, sex, and SES as covariates
| Grey matter density | Grey matter Volumes | |||||||
|---|---|---|---|---|---|---|---|---|
| MNI Coordinate | Region | Brodmann Area |
T | FDR corrected p | HSV1 Neg (cc) | HSV1 Pos (cc) | F (1, 19) |
p |
| Regression model for grey matter volumes including MICB genotypes, Age, Sex and SES | ||||||||
| 54 8 34 | R Inf Frontal G | BA 9 | 6.72 | 0.003 | 7.51±0.65 | 6.38±0.20 | 11.38 | 0.003 |
| −54 −6 40 | L Precentral G | BA 6 | 5.39 | 0.007 | 3.76±0.43 | 3.32±0.48 | 5.11 | 0.036 |
| −12 68 10 | L Medial Frontal G | BA 10 | 4.85 | 0.011 | 0.68±0.08 | 0.59±0.06 | 8.74 | 0.008 |
| 8 6 50 | R Dorsal Ant Cingulate G | BA 32 | 4.45 | 0.018 | 0.14±0.02 | 0.12±0.02 | 5.51 | 0.03 |
| −2 8 34 | L Ant Cingulate G | BA 24 | 3.92 | 0.032 | 0.12±0.01 | 0.11±0.01 | 3.76 | 0.067 |
| −48 44 −6 | L Mid Frontal G | BA 47 | 3.79 | 0.037 | 0.18±0.02 | 0.14±0.02 | 20.71 | 0.0002 |
| −46 −66 46 | L Inf Par Lobule | BA 39 | 3.70 | 0.041 | 0.17±0.03 | 0.15±0.03 | 3.82 | 0.066 |
| −56 −34 48 | L Inf Par Lobule | BA 40 | 3.84 | 0.037 | 0.15±0.01 | 0.14±0.02 | 2.74 | 0.11 |
| Regression model for grey matter volumes including Age, Sex and SES but not MICB genotypes | ||||||||
| −6 28 42 −56 −4 36 −38 10 52 |
L Med/Mid Frontal & Precentral G |
BA 6 | 5.50 5.87 7.06 |
0.024 0.016 0.005 |
1.05±0.12 | 1.14±0.13 | 5.19 | 0.028 |
| −8 −48 −42 | L Posterior Cingulate G | BA 31 | 4.43 | 0.054* | 0.16±0.02 | 0.14±0.02 | 5.08 | 0.036 |
| 60 −2 0 | R Superior Temporal G | BA 22 | 5.42 | 0.026 | 0.25±0.03 | 0.21±0.05 | 4.54 | 0.046 |
| 24 42 40 54 6 40 |
R Superior Frontal G R Middle Frontal G |
BA 9 | 5.51 10.92 |
0.024 0.001 |
6.52±0.76 | 5.84±0.89 | 3.55 | 0.075 |
| −58 −26 38 | L Postcentral G | BA 2 | 5.17 | 0.033 | 0.36±0.05 | 0.33±0.04 | 3.59 | 0.073 |
| 26 −8 −38 | R Uncus | BA 28 | 5.37 | 0.027 | 0.17±0.03 | 0.15±0.03 | 3.14 | 0.092 |
| −48 12 28 | L Inf Frontal G | BA 9 | 5.13 | 0.033 | 0.34±0.05 | 0.31±0.04 | 2.11 | 0.163 |
| 22 −56 58 | R Precuneus | BA 7 | 5.26 | 0.030 | 0.11±0.03 | 0.09±0.03 | 1.84 | 0.190 |
| 28 −22 58 | R Precentral G | BA 4 | 4.75 | 0.044 | 0.08±0.02 | 0.07±0.02 | 0.12 | 0.730 |
| 8 2 50 | R Anterior Cingulate G | BA 24 | 5.91 | 0.015 | 3.96±0.48 | 3.58±0.57 | 0.06 | 0.809 |
*
This is included here because we observed changes in the cingulate gyrus in our previous publication (Prasad et al., 2007)