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. Author manuscript; available in PMC: 2011 Mar 1.
Published in final edited form as: J Neurochem. 2009 Nov 6;112(6):1431–1441. doi: 10.1111/j.1471-4159.2009.06479.x

Fig. 6. Opioids stimulate oligodendrogenesis from ESC-derived glial progenitors via ERK and p38 pathways.

Fig. 6

Glial progenitors were exposed to DAMGO (1 μM) or U69,593 (1 μM) +/− UO126 (1 μM) or SB23906 (500 nM) for 9 days. The inhibitors were added to cells 1 h prior and during opioid treatment. Fresh agonists and inhibitors were added on a daily basis. Then cells were fixed, permeabilized and labeled with a mouse monoclonal anti-O4 Ab, secondary Ab and DAPI as described in figure 5. (A) Representative images of O4+ (red) and DAPI+ (blue) cells. (B) O4+ cell counting data are expressed as %oligodendrocytes vs. total number of DAPI+ cells. N = 3–6. **P<0.01 vs. controls; #P<0.05, ##P<0.01 vs. agonist alone.