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. Author manuscript; available in PMC: 2011 May 1.
Published in final edited form as: J Struct Biol. 2010 Feb 10;170(2):344–353. doi: 10.1016/j.jsb.2010.02.001

Figure 1. Fiber-type specific induction of MuRF1 during denervation.

Figure 1

A) Specificity of the used antibody and blotting conditions for MuRF1 as indicated by the absence of MuRF1 signal in MuRF1-KO extracts. In WT, MuRF1 was induced about twofold by denervation (DEN) in both in soleus (SO) and tibialis anterior (TA) muscles.

B) SO and C) TA muscles were examined 14 days after N. ischiadicus lesion with antibodies specific for MuRF1, type-I MHC (MHC I), and type II MHC (MHC II). From left to right, immunohistochemistry with MuRF1, MHC-I, or MHC-II antibdodies. MuRF1 is expressed preferentially in type-II muscle fibers. 400x.

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