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. Author manuscript; available in PMC: 2011 May 1.
Published in final edited form as: J Struct Biol. 2010 Feb 10;170(2):344–353. doi: 10.1016/j.jsb.2010.02.001

Figure 2. Time-course of induction of MuRF1 and MuRF2 and MuRF-associated proteins after denervation as determined by Western blot studies.

Figure 2

A) Protein expression of MuRF1 and MuRF2 after denervation (DEN) in quadriceps was monitored at 5 and 14 days. MuRF1 is induced 5 days after DEN. At 14 days, MuRF1 is still elevated, but appears as a slightly faster migrating doublet, possibly indicating its degradation.

B) MuRF2’s 60 kDa isoform is not significantly altered in expression before and after DEN. However, a 50 kDa splice isoform is induced by denervation.

C, D) In contrast to MuRF1, atrogin-1 was not significantly altered in expression at day 14 in both in soleus (SO) and tibialis anterior (TA). Histograms show the relative protein expression and bars represent the mean of each group expressed in arbitrary units (A.U.) with indicated the standard deviation.

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