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. Author manuscript; available in PMC: 2011 May 1.
Published in final edited form as: J Struct Biol. 2010 Feb 10;170(2):344–353. doi: 10.1016/j.jsb.2010.02.001

Figure 5. Effect of combined MuRF1/MuRF2 deletion and MuRF1 overexpression on muscle fiber type distribution.

Figure 5

Type I and type II fibers were detected by immunofluorescence with antibodies specific for MHCI and MHCII, respectively (left), and their relative frequencies were determined in tibialis anterior (TA) and soleus (SO) (right) of WT, dKO, and MuRF1-overexpressing (MuRF1-TG) mice. Black bars represent type I, white bars type II and grey bars intermediate fiber type occurrence as percentile of total fibers.

A) Combined inactivation of MuRF1 and MuRF2 did not affect the pure type-II fiber type found in TA. 100x.

B) SO from dKO mice was markedly enriched in type-I fibers. 100x.

C) Overexpression of MuRF1 did not affect fiber-type distribution (see text for details). 100x.

Data are expressed as mean ± SD; n= 3 whole cross-sections; *p<0.05 vs. WT.

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