Table 1.
Clinical characteristics of patients taking LDA enrolled in the present study
| Patients with ulcer (n = 119) | Patients without ulcer (n = 334) | P-value | |
| Gender (male/female) | 87/32 | 211/123 | NS |
| Age (yr), median (range) | 73.0 (47-92) | 72.0 (45-95) | NS |
| Male (n = 298) | 70.0 (47-92) | 71.0 (43-93) | NS |
| Female (n = 155) | 77.0 (54-92) | 73.0 (47-95) | 0.0338 |
| Underlying disease (male/female) | |||
| Ischemic heart disease | 77 (61/16) | 205 (131/74) | NS |
| Cerebral infarction | 22 (10/12) | 70 (39/31) | NS |
| Atrial fibrillation | 16 (13/3) | 43 (28/15) | NS |
| Others | 4 (3/1) | 16 (13/3) | NS |
| Symptoms (male/female) | |||
| Melena, hematemesis | 46 (29/17) | 1 (0/1) | < 0.0001 |
| GI symptoms | 31 (21/10) | 107 (72/35) | NS1 |
| Anemia | 17 (14/3) | 40 (21/19) | 0.0156 |
| Body weight loss | 1 (1/0) | 7 (5/2) | 0.0087 |
| Appetite loss | 1 (1/0) | 8 (2/6) | 0.0028 |
| None (medical check) | 18 (15/3) | 146 (96/50) | 0.0025 |
| Others | 5 (2/0) | 25 (15/10) | > 0.9999 |
| Helicobacter pylori | 62.3% (43/69) | - | |
| Male | 66.7% (30/45) | - | |
| Female | 54.2% (13/24) | - | |
1
Forty-six patients presented with melena and/or hematemesis and bleeding source in the stomach or duodenum identified by endoscopy and were excluded from GI symptoms in this analysis. LDA: Low-dose aspirin; GI: Gastrointestinal; NS: Not significant.