Table 2.
Univariate analysis to identify factors predictive of LDA-associated gastroduodenal ulcer in male and female patients
| Factor |
Male patients (n = 299) |
Female patients (n = 155) |
||||
| Patients with ulcer (n = 87) | Patients without ulcer (n = 211) | P-value | Patients with ulcer (n = 32) | Patients without ulcer (n = 123) | P-value | |
| PPIs | 1 | 22 | 0.0038 | 0 | 18 | 0.0253 |
| H2RAs | 16 | 53 | NS | 5 | 38 | NS |
| Muco-protective agents | 18 | 40 | NS | 6 | 18 | NS |
| Hypertension | 62 | 150 | NS | 21 | 88 | NS |
| Hyperlipidemia | 36 | 96 | NS | 14 | 51 | NS |
| History of peptic ulcer | 18 | 19 | 0.0109 | 9 | 9 | 0.0030 |
| Diabetes mellitus | 29 | 63 | NS | 11 | 30 | NS |
| Insulin therapy | 4 | 12 | NS | 3 | 3 | NS |
| Anticoagulants | 29 | 87 | NS | 11 | 35 | NS |
| NSAIDs | 3 | 25 | NS | 3 | 10 | NS |
| Age ≥ 70 yr | 45 | 123 | NS | 28 | 85 | 0.0443 |
| Alcohol | 28 | 63 | NS | 6 | 12 | NS |
| Smoking | 22 | 36 | NS | 1 | 8 | NS |
PPIs: Proton-pump inhibitors; H2RAs: Histamine type 2 receptor antagonists; NSAIDs: Nonsteroidal anti-inflammatory drugs.